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ISSN: Print -2349-0977, Online - 2349-4387
ORIGINAL CONTRIBUTION: CURRENT APPROACHES IN STROKE MEDICINE
Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 12-15

Significance of statins and antiplatelet molecules in hyperacute acute ischemic stroke outcome


1 Department of Neurology, University of Massachusetts, Worcester, MA, USA
2 Department of Neuro-Critical Care, Massachusetts General Hospital, Boston, MA, USA
3 Department of Biostatistics, University of Massachusetts, Worcester, MA, USA

Correspondence Address:
Prof. Majaz Moonis
Director, Stroke Services, UMass Memorial Medical Center, Worcester, Massachusetts 01655
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-0977.168246

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Introduction: Ischemic stroke is a major cause of morbidity and mortality. However, the interface of various premorbid medical conditions, vascular risk factors prior, prior antithrombotic or statins medication use, and in-hospital complications in effecting outcomes is not clearly established. We attempt establishing factors associated with improved outcomes after an acute ischemic stroke (AIS). Materials and Methods: Using the prospectively collected database, University Health Consortium from 1999 to 2004, a national USA database, multivariate step-wise backward regression analysis was performed and we were able to define premorbid characteristics, and medications that affect the outcome of AIS. Results: Initial stroke severity and poststroke in-hospital complications were associated with a poor outcome, while prior antiplatelet drug use was associated with an improved outcome. Statin use demonstrated a trend toward an improved outcome.


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