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ISSN: Print -2349-0977, Online - 2349-4387
CASE IN POINT: CLINICS IN INTERNAL MEDICINE
Year : 2015  |  Volume : 2  |  Issue : 3  |  Page : 151-154

Correlation of serum methotrexate levels with drug induced side effects


1 Department of Medicine, Indraprastha Apollo, Sarita Vihar, New Delhi, India
2 Department of Pediatrics, Jagrani Hospital, Lucknow, Uttar Pradesh, India
3 Department of Pathology, Yenepoya University, Mangalore, Karnataka, India

Correspondence Address:
Saumya H Mittal
Department of Medicine, Indraprastha Apollo, Sarita Vihar, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-0977.181506

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Often employed in the treatment of malignancies with high cellular proliferation rates, including acute lymphoblastic leukemia, choriocarcinoma, trophoblastic tumours, and carcinomas of the breast, tongue, pharynx, and testis; and certain nonmalignant conditions like rheumatoid arthritis, psoriasis, asthma, sarcoidosis, and transplantation therapy, methotrexate is an antifolate agent. It works by inhibiting the enzyme dihydrofolate reductase. The molecule inhibits DNA synthesis by depletion of nucleotide precursors and is associated with a number of diverse side effects. The present series comprises of 4 patients: Each demonstrated significant drug-induced side effects even though their serum methotrexate levels were found to be normal.


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