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ISSN: Print -2349-0977, Online - 2349-4387
PRACTICE CHANGING CONTINUING EDUCATION - NEUROLOGICAL COMPLICATIONS IN ACUTE PANCREATITIS
Year : 2016  |  Volume : 2  |  Issue : 4  |  Page : 185-186

The uncommon syndrome of pancreatic encephalopathy


1 Department of Neurology, KMC Hospital, Mangalore, Karnataka, India
2 Department of Pathology, KMC Hospital, Mangalore, Karnataka, India
3 Detroit Medical Centre, Children's Hospital of Michigan, Detroit, Michigan, USA

Correspondence Address:
Saumya H Mittal
Department of Neurology, KMC Hospital, Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-0977.191047

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Even though first described in 1923, the syndrome of pancreatic encephalopathy is an uncommon complication of acute pancreatitis. A multiple organ dysfunction syndrome, it generally occurs in early stage of severe acute pancreatitis and carries a high mortality of up to 57% and more. The syndrome must be distinguished from Wernicke encephalopathy, which may follow as a part of neurological complications in the last or restoration stage of acute pancreatitis, and occurs as a result of long fasting, hyperemesis and total parenteral nutrition without thiamine. Poorly recognized by clinicians, a large dose of Vitamin B1 is effective in the management of Wernicke encephalopathy. The present article draws attention to the two lesser recognized complications of acute pancreatitis and briefly dwells on their pathogenesis and management.


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