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ISSN: Print -2349-0977, Online - 2349-4387
Year : 2018  |  Volume : 4  |  Issue : 4  |  Page : 240-250

Pituitary tumors: Changing paradigms in understanding, nomenclature and the newer basis of classification

Department of Pathology, Institute of Human Behaviour and Allied Sciences, Delhi, India

Correspondence Address:
Sujata Chaturvedi
Department of Pathology, Institute of Human Behaviour and Allied Sciences, Dilshad Garden, Delhi - 110 095
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/astrocyte.astrocyte_43_18

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The pituitary gland is embryologically divided into two main lobes: adenohypophysis (anterior) and neurohypophysis (posterior). Last five decades have witnessed changes in the tumor classifications – anterior pituitary in 2017 and posterior in 2016, based on hormonal immunohistochemistry, molecular profiles, and pituitary specific transcription factors. Few newer entities/terms have been added and at the same time certain terms have been modified/discarded. In this article, relevant anatomy, development, histology, incidence, and clinical manifestations of pituitary tumors evolution of various classification systems and recommended current classification of pituitary tumors; the genetic alterations and the diagnostic implications for today's pathologist have been reviewed in a comprehensive manner.

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